Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's
lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and …

Atopic asthma is an inflammatory pulmonary disease associated with Th2 adaptive immune
responses triggered by innocuous antigens. While dendritic cells (DCs) are known to shape …

Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon
antigen recall. How this decision is programmed is not understood. We found that the …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

The interferon regulatory factors (IRF) consist of a growing family of related transcription
proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters …

B cells producing high-affinity antibodies are destined to differentiate into memory B cells
and plasma cells, but the mechanisms leading to those differentiation pathways are mostly …

Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU. 1 or …