Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator
Platelet-derived growth factor C (PDGF-C) is one of four members in the PDGF family of
growth factors, which are known mitogens and survival factors for cells of mesenchymal …
growth factors, which are known mitogens and survival factors for cells of mesenchymal …
From clinic to mechanism: Proteomics‐based assessment of angiogenesis in adrenal pheochromocytoma
F Sun, R Zhuo, W Ma, D Yang, T Su… - Journal of Cellular …, 2019 - Wiley Online Library
Adrenal pheochromocytoma (PCC) is a very rare tumor that stems from chromaffin cells,
which can develop into malignant tumor. During the operation, abundant blood vessels were …
which can develop into malignant tumor. During the operation, abundant blood vessels were …
Designing rt-PA Analogs to Release its Trapped Thrombolytic Activity
W Li - Journal of Computational Biophysics and Chemistry, 2021 - World Scientific
Recombinant tissue-type plasminogen activator (rt-PA, alteplase) is an FDA-approved
thrombolytic drug. Designing rt-PA analogs to suppress its inhibition by plasminogen …
thrombolytic drug. Designing rt-PA analogs to suppress its inhibition by plasminogen …
Inhibition of pathological retinal neovascularization by a small peptide derived from human tissue-type plasminogen kringle 2
Q Sun, Y Shen, L Su, X Xu - Frontiers in Pharmacology, 2020 - frontiersin.org
Retinal neovascularization is a hallmark pathological process of numerous ocular diseases
which comprise the most common causes of blindness and affect millions of people from …
which comprise the most common causes of blindness and affect millions of people from …
The naive murine cornea as a model system to identify novel endogenous regulators of lymphangiogenesis: TRAIL and rtPA
B Regenfuß, ML Dreisow, D Hos, S Masli… - … research and biology, 2015 - liebertpub.com
Background: In the murine cornea, which is an established model for analyzing pathologic
lymphatic vessel growth, phenotypic heterogeneity of the endogenous lymphatic vessels in …
lymphatic vessel growth, phenotypic heterogeneity of the endogenous lymphatic vessels in …
[HTML][HTML] RNA sequencing reveals transcriptomic changes in PC-12 cells following plasminogen activator, tissue type overexpression
Y Mao, C Fang, J Zhao, X Huang, W He… - Translational …, 2024 - pmc.ncbi.nlm.nih.gov
Background Pheochromocytoma and paraganglioma, collectively known as PPGL, are
categorized as neuroendocrine tumors with the potential for malignancy. Plasminogen …
categorized as neuroendocrine tumors with the potential for malignancy. Plasminogen …
Antimigratory effect of TK1-2 is mediated in part by interfering with integrin α2β1
HK Kim, DS Oh, SB Lee, JM Ha, YA Joe - Molecular cancer therapeutics, 2008 - AACR
The recombinant two kringle domain of human tissue-type plasminogen activator (TK1-2)
has been shown to inhibit endothelial cell proliferation, angiogenesis, and tumor cell growth …
has been shown to inhibit endothelial cell proliferation, angiogenesis, and tumor cell growth …
In vitro and in vivo antiangiogenic activity of a novel deca-peptide derived from human tissue-type plasminogen activator kringle 2
L Su, X Xu, H Zhao, Q Gu, H Zou - Biochemical and biophysical research …, 2010 - Elsevier
A synthetic deca-peptide corresponding to the amino acid sequence Arg54-Trp63 of human
tissue-type plasminogen activator (t-PA) kringle 2 domain, named TKII-10, is produced and …
tissue-type plasminogen activator (t-PA) kringle 2 domain, named TKII-10, is produced and …
A Novel Peptide Derived From Tissue‐Type Plasminogen Activator Potently Inhibits Angiogenesis and Corneal Neovascularization
HK Kim, JS Choi, SW Lee, CK Joo… - Journal of Cellular …, 2017 - Wiley Online Library
ABSTRACT The recombinant protein TK1‐2, which consists of two kringle domains of tissue‐
type plasminogen activator (t‐PA), inhibits angiogenesis and tumor growth. ɪn this study, we …
type plasminogen activator (t‐PA), inhibits angiogenesis and tumor growth. ɪn this study, we …
DGDA, a local sequence of the kringle 2 domain, is a functional motif of the tissue-type plasminogen activator's antiangiogenic kringle domain
HK Kim, YA Joe - Biochemical and biophysical research communications, 2010 - Elsevier
Antiangiogenic activity can be elicited by the kringle domains 1 and 2 of tissue-type
plasminogen activator (TK1–2), or the kringle 2 domain alone. In a previous report, we …
plasminogen activator (TK1–2), or the kringle 2 domain alone. In a previous report, we …