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Recent advances in extracellular vesicles for therapeutic cargo delivery
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest
in the field of biomedical research due to their unique properties, including biocompatibility …
in the field of biomedical research due to their unique properties, including biocompatibility …
Recent advances in extracellular vesicle engineering and its applications to regenerative medicine
Extracellular vesicles (EVs) are nanosized particles that are released from cells and reflect
the characteristics of the mother cell. Recently, the EVs have been used in several types of …
the characteristics of the mother cell. Recently, the EVs have been used in several types of …
Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
Background Epilepsy affects∼ 60 million people worldwide. Most antiseizure medications in
the market act on voltage-gated sodium or calcium channels, indirectly modulating …
the market act on voltage-gated sodium or calcium channels, indirectly modulating …
[HTML][HTML] Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway
F Sun, Y Sun, X Wang, J Zhu, S Chen, Y Yu, M Zhu… - Bioactive Materials, 2024 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness worldwide with limited treatment
options. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) hold …
options. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) hold …
Advances in Extracellular-Vesicles-Based Diagnostic and Therapeutic Approaches for Ocular Diseases
Y Su, M Chen, W Xu, P Gu, X Fan - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) are nanoscale membrane vesicles of various sizes that can be
secreted by most cells. EVs contain a diverse array of cargo, including RNAs, lipids …
secreted by most cells. EVs contain a diverse array of cargo, including RNAs, lipids …
[HTML][HTML] Neural stem cell-derived extracellular vesicles: the light of central nervous system diseases
Y Li, B Fang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Central nervous system (CNS) diseases are the leading cause of death worldwide. By
performing compensatory functions and improving the inflammatory microenvironment, the …
performing compensatory functions and improving the inflammatory microenvironment, the …
Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics
J Roerig, M Schulz‐Siegmund - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are widely recognized for their potential as drug delivery
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …
Cell and molecular targeted therapies for diabetic retinopathy
Diabetic retinopathy (DR) stands as a prevalent complication in the eye resulting from
diabetes mellitus, predominantly associated with high blood sugar levels and hypertension …
diabetes mellitus, predominantly associated with high blood sugar levels and hypertension …
[HTML][HTML] Small extracellular vesicles of organoid-derived human retinal stem cells remodel Müller cell fate via miRNA: A novel remedy for retinal degeneration
S Huang, Y Zeng, Q Guo, T Zou, ZQ Yin - Journal of Controlled Release, 2024 - Elsevier
Remodeling retinal Müller glial fate, including gliosis inhibition and pro-reprogramming,
represents a crucial avenue for treating degenerative retinal diseases. Stem cell …
represents a crucial avenue for treating degenerative retinal diseases. Stem cell …
[HTML][HTML] Utilizing extracellular vesicles as a drug delivery system in glaucoma and RGC degeneration
E Durmaz, L Dribika, M Kutnyanszky, B Mead - Journal of Controlled …, 2024 - Elsevier
Retinal diseases are the leading cause of blindness, resulting in irreversible degeneration
and death of retinal neurons. One such cell type, the retinal ganglion cell (RGC), is …
and death of retinal neurons. One such cell type, the retinal ganglion cell (RGC), is …