Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Alzheimer's disease (AD) research has entered a new era with the recent positive phase 3
clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years …

The discovery of a pathogenic variant in the alpha-synuclein (SNCA) gene in the Contursi
kindred in 1997 indisputably confirmed a genetic cause in a subset of Parkinson's disease …

Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …

The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …

The tauopathies encompass over 20 adult neurodegenerative diseases and are
characterized by the dysfunction and accumulation of insoluble tau protein. Among them …

Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by
problems with movement, balance, and cognition. PSP differs from Alzheimer's disease (AD) …

Tauopathies are a heterogeneous group of neurologic diseases characterized by
pathological axodendritic distribution, ectopic expression, and/or phosphorylation and …

Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease
characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and …