The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …

Subcellular localization of messenger RNAs (mRNAs), as a prevalent mechanism, gives
precise and efficient control for the translation process. There is mounting evidence for the …

The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes
are tightly correlated with the rate of cell growth and proliferation. All these processes must …

An essential task in spatial transcriptomics is identifying spatially variable genes (SVGs).
Here, we present Celina, a statistical method for systematically detecting cell type-specific …

The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition
in cancer. Drug discovery efforts center on the blockade of the" WIN site" of WDR5, a well …

Background Biomarkers that reflect glioblastoma tumour activity and treatment response are
urgently needed to help guide clinical management, particularly for recurrent disease. As the …

Subcellular localization of messenger RNAs (mRNAs) plays a key role in the spatial
regulation of gene activity. The functions of mRNAs have been shown to be closely linked …

Abstract Background Hyperactive RNA Polymerase I (Pol I) transcription is canonical in
cancer, associated with malignant proliferation, poor prognosis, epithelial-mesenchymal …

Modulation of the cervix by steroid hormones and commensal microbiome play a central role
in the health of the female reproductive tract. Here we describe organ-on-a-chip (Organ …

Simple Summary Building ribosomes for cellular protein translation is a massive, energy-
consuming undertaking. The process is executed by all cells to replenish the relevant pools …