Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter
release and in triggering alterations in neuronal function. Calmodulin has been widely …

Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins
and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously …

Phototransduction is the process by which light triggers an electrical signal in a
photoreceptor cell. Image-forming vision in vertebrates is mediated by two types of …

For decades, photoreceptors have been an outstanding model system for elucidating basic
principles in sensory transduction and biochemistry and for understanding many facets of …

Congenital stationary night blindness (CSNB) is an inherited retinal disease that causes a
profound loss of rod sensitivity without severe retinal degeneration. One well-studied …

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

The cone and cone–rod dystrophies form part of a heterogeneous group of retinal disorders
that are an important cause of visual impairment in children and adults. There have been …

For over 30 years, photoreceptors have been an outstanding model system for elucidating
basic principles in sensory transduction and G protein signaling. Recently, photoreceptors …

The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …