Dopamine replacement therapy with l-DOPA is the most efficacious symptomatic treatment
for Parkinson's disease, but its utility is limited by a development of motor fluctuations and …

Levodopa‐induced motor complications remain an important source of disability for many
patients with Parkinson's disease. Substantial laboratory evidence indicates that motor …

Spreading depolarizations (SDs) are self-propagating waves of mass depolarization that
cause silencing of brain activity and have the potential to impact brain function and behavior …

Extrapyramidal movement disorders include hypokinetic rigid and hyperkinetic or mixed
forms, most of them originating from dysfunction of the basal ganglia (BG) and their …

Spreading depolarization (SD) is an electrochemical wave of neuronal depolarization
mediated by extracellular K+ and glutamate, interacting with voltage‐gated and ligand …

Paroxysmal movement disorders include paroxysmal kinesigenic dyskinesia, paroxysmal
non-kinesigenic dyskinesia, paroxysmal exercise-induced dyskinesia, and episodic ataxias …

Migraine with its high prevalence, complex pathogenesis, including changes in the nervous,
immune, cardiovascular systems, and limited effectiveness of drug treatment, is one of the …

Parkinson's disease (PD) is a neurodegenerative disorder characterised by typical motor
symptoms that are caused by severe dopamine depletion in the cortico-basal ganglia …

Результаты многочисленных исследований свидетельствуют об участии
воспалительных процессов в развитии болезни Паркинсона (БП). Теория «бей и …

Background. Parkinson's disease (PD) is a multisystem disease that requires a more
comprehensive approach to its study and treatment. The purpose was to give clinical and …