[HTML][HTML] Justicidin B: a promising bioactive lignan

S Hemmati, H Seradj - Molecules, 2016‏ - mdpi.com
Adverse effects and drug resistance to the current onchopharmacologicals have increased
the demand for alternative novel therapeutics. We herein introduce justicidin B, an …

Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties

A Mohagheghzadeh, P Badr, A Mohagheghzadeh… - Pharmaceuticals, 2023‏ - mdpi.com
Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis,
cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is …

Biosynthesis of phenylpropanoids and related compounds

M Petersen, J Hans, U Matern - Annual Plant Reviews Volume …, 2010‏ - Wiley Online Library
Phenolic compounds are ubiquitous in the plant kingdom. A main pathway for the formation
of these compounds starts with the aromatic amino acids L‐phenylalanine and–to a lesser …

Arylnaphthalene Lignans with Anti-SARS-CoV-2 and Antiproliferative Activities from the Underground Organs of Linum austriacum and Linum perenne

G Toth, K Horváti, M Kraszni, T Ausbuttel… - Journal of Natural …, 2023‏ - ACS Publications
Diphyllin (1) and justicidin B (2) are arylnaphthalene lignans with antiviral and
antiproliferative effects. Compound 1 is also known as an effective inhibitor of the Severe …

Lignans in flowering aerial parts of Linum species–chemodiversity in the light of systematics and phylogeny

TJ Schmidt, S Hemmati, M Klaes, B Konuklugil… - Phytochemistry, 2010‏ - Elsevier
The aerial parts of 54 accessions representing 41 Linum species and four species of related
genera were analysed for lignans by means of HPLC-ESI/MS–MS-UV/DAD. In total, 64 …

A comprehensive review on rhubarb astringent/laxative actions and the role of aquaporins as hub genes

G Mosleh, M Zaeri, S Hemmati… - Phytochemistry …, 2023‏ - Springer
Rhubarb, the rhizome and root of Rheum palmatum L. from the Polygonaceae family, is a
globally important medicinal plant, especially in eastern Asia. It has been indicated for …

Considerations on the rational design of covalently conjugated cell-penetrating peptides (CPPs) for intracellular delivery of proteins: a guide to CPP selection using …

Y Behzadipour, S Hemmati - Molecules, 2019‏ - mdpi.com
Access of proteins to their intracellular targets is limited by a hydrophobic barrier called the
cellular membrane. Conjugation with cell-penetrating peptides (CPPs) has been shown to …

Introducing a delivery system for melanogenesis inhibition in melanoma B16F10 cells mediated by the conjugation of tyrosine ammonia‐lyase and a TAT‐penetrating …

Y Behzadipour, I Sadeghian… - Biotechnology …, 2021‏ - Wiley Online Library
Hyperpigmentation disorders negatively influence an individual's quality of life and may
cause emotional distress. Over the years, various melanogenesis inhibitors (mainly …

Humanizing plant-derived snakins and their encrypted antimicrobial peptides

Z Ghanbarzadeh, S Hemmati, A Mohagheghzadeh - Biochimie, 2022‏ - Elsevier
Due to safety restrictions, plant-derived antimicrobial peptides (AMPs) need optimization to
be consumed beyond preservatives. Herein, 175 GASA-domain-containing snakins were …

Effect of alumina (Al2O3) nanoparticles and macroparticles on Trigonella foenum-graceum L. in vitro cultures: assessment of growth parameters and oxidative …

H Owji, S Hemmati, R Heidari, M Hakimzadeh - 3 Biotech, 2019‏ - Springer
The impact of 100 μg ml− 1 alumina (Al 2 O 3) nanoparticles (NPs) on Trigonella foenum
(fenugreek) in vitro cultures was studied within 3 weeks (on days 1, 7, 14, and 21) and …