Background Breast cancer is the most prevalent cancer among women worldwide and the
fifth cause of death among all cancer patients. Breast cancer development is driven by …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in
mice, there has been considerable interest in the role of NF-κB signaling in bone. NF-κB …

Many inflammation-associated diseases, including cancers, increase in women after
menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

Breast cancer is a heterogeneous disease, which over time acquires various adaptive
changes leading to more aggressive biological characteristics and development of treatment …