The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

While for a century therapeutics has been dominated by small molecules, ie organic
chemicals of~ 400Da absorbable via the gut, this is no longer the case. There are now a …

Postoperative cognitive dysfunction (POCD) is an objectively measured decline in cognition
postoperatively compared with preoperative function. POCD has been considered in the …

Neuroinflammation has become a key hallmark of neurological complications including
perioperative pathologies such as postoperative delirium and longer-lasting postoperative …

General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

Injury is a key driver of inflammation, a critical yet necessary response involving several
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …

Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Postoperative cognitive dysfunction (POCD) affects the outcome of millions of patients each
year. Aging is a risk factor for POCD. Here, we showed that surgery induced learning and …

Postoperative cognitive dysfunction (POCD) is a common neurological complication
following surgery and general anesthesia, especially in elderly patients. Severe cases delay …

Objective: Cognitive decline accompanies acute illness and surgery, especially in the
elderly. Surgery engages the innate immune system that launches a systemic inflammatory …