The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Parkinson's disease-causing mutations in the leucine-rich repeat kinase 2 (LRRK2) gene
hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases …

Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

Cytoplasmic dynein is essential for intracellular transport. Despite extensive in vitro
characterizations, how the dynein motors transport vesicles by processive steps in live cells …

The interior of a living cell is a crowded, heterogenuous, fluctuating environment. Hence, a
major challenge in modeling intracellular transport is to analyze stochastic processes within …

Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

Autophagy is an essential cellular degradation pathway in neurons; defects in autophagy
are sufficient to induce neurodegeneration. In this paper, we investigate autophagosome …