Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Since the discovery of electron-wave duality, electron scattering instrumentation has
developed into a powerful array of techniques for revealing the atomic structure of matter …

Many patients with advanced cancers achieve dramatic responses to a panoply of
therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse …

Ancient Egyptians believed cancer to be a curse, as seen from evidence as old as 3000 BC
from the Edwin Smith Papyrus which described breast cancer and Ebers Papyrus dated …

Malignant transformation can result in melanoma cells that resemble different stages of their
embryonic development. Our gene expression analysis of human melanoma cell lines and …

Therapies that target signalling molecules that are mutated in cancers can often have
substantial short-term effects, but the emergence of resistant cancer cells is a major barrier …

Abstract Treatment options for patients with metastatic melanoma, and especially BRAF-
mutant melanoma, have changed dramatically in the past 5 years, with the FDA approval of …

Cultured cell lines are the workhorse of cancer research, but the extent to which they
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …

Malignant melanoma is notorious for its inter-and intratumour heterogeneity, based on
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …