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[HTML][HTML] Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels
Thyroid hormones are necessary for the normal functioning of physiological systems.
Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters …
Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters …
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
The genetic basis of thyroid function: novel findings and new approaches
A Kuś, L Chaker, A Teumer, RP Peeters… - The Journal of Clinical …, 2020 - academic.oup.com
Context Genetic factors are major determinants of thyroid function. Over the last two
decades, multiple genetic variants have been associated with variations in normal range …
decades, multiple genetic variants have been associated with variations in normal range …
Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease
Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …
Retrospective analysis of the correlation between uric acid and thyroid hormone in people with normal thyroid function
G Chao, Y Zhu, L Fang - Journal of Diabetes Research, 2019 - Wiley Online Library
Objective. This study adopts the method of retrospective analysis to collect general
information and laboratory results of physical examination population, ho** to clarify the …
information and laboratory results of physical examination population, ho** to clarify the …
Genetic thyrotropin regulation of atrial fibrillation risk is mediated through an effect on height
Context A genetic predisposition to lower thyrotropin (TSH) levels is associated with
increased atrial fibrillation (AF) risk through undefined mechanisms. Objective Defining the …
increased atrial fibrillation (AF) risk through undefined mechanisms. Objective Defining the …
Identifying datasets for cross-study analysis in dbGap using PhenX
H Pan, V Bakalov, L Cox, ML Engle, SW Erickson… - Scientific Data, 2022 - nature.com
Identifying relevant studies and harmonizing datasets are major hurdles for data reuse.
Common Data Elements (CDEs) can help identify comparable study datasets and reduce …
Common Data Elements (CDEs) can help identify comparable study datasets and reduce …
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
S Yoshioka, Y Arakawa, M Hasegawa, S Kato… - …, 2024 - Taylor & Francis
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we
evaluated the association of DNA methylation with free thyroxine (FT4) and TSH …
evaluated the association of DNA methylation with free thyroxine (FT4) and TSH …
Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function
X Ke, X Tian, S Yao, H Wu, YY Duan… - Human Molecular …, 2022 - academic.oup.com
Thyroid dysfunction is a common endocrine disease measured by thyroid-stimulating
hormone (TSH) level. Although> 70 genetic loci associated with TSH have been reported …
hormone (TSH) level. Although> 70 genetic loci associated with TSH have been reported …
Mendelian Randomisation Analysis Suggests that Hypothyroidism Reduces Endometrial Cancer Risk
Background Thyroid dysfunction, hypothyroidism in particular, has been associated with
endometrial cancer, but it remains unclear whether hypothyroidism itself or other aspects of …
endometrial cancer, but it remains unclear whether hypothyroidism itself or other aspects of …