[HTML][HTML] Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels

M Babić Leko, I Gunjača, N Pleić… - International journal of …, 2021 - mdpi.com
Thyroid hormones are necessary for the normal functioning of physiological systems.
Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters …

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

The genetic basis of thyroid function: novel findings and new approaches

A Kuś, L Chaker, A Teumer, RP Peeters… - The Journal of Clinical …, 2020 - academic.oup.com
Context Genetic factors are major determinants of thyroid function. Over the last two
decades, multiple genetic variants have been associated with variations in normal range …

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease

AT Williams, J Chen, K Coley, C Batini… - Nature …, 2023 - nature.com
Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …

Retrospective analysis of the correlation between uric acid and thyroid hormone in people with normal thyroid function

G Chao, Y Zhu, L Fang - Journal of Diabetes Research, 2019 - Wiley Online Library
Objective. This study adopts the method of retrospective analysis to collect general
information and laboratory results of physical examination population, ho** to clarify the …

Genetic thyrotropin regulation of atrial fibrillation risk is mediated through an effect on height

M Shi, AM Manouchehri, CM Shaffer… - The Journal of …, 2021 - academic.oup.com
Context A genetic predisposition to lower thyrotropin (TSH) levels is associated with
increased atrial fibrillation (AF) risk through undefined mechanisms. Objective Defining the …

Identifying datasets for cross-study analysis in dbGap using PhenX

H Pan, V Bakalov, L Cox, ML Engle, SW Erickson… - Scientific Data, 2022 - nature.com
Identifying relevant studies and harmonizing datasets are major hurdles for data reuse.
Common Data Elements (CDEs) can help identify comparable study datasets and reduce …

Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range

S Yoshioka, Y Arakawa, M Hasegawa, S Kato… - …, 2024 - Taylor & Francis
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we
evaluated the association of DNA methylation with free thyroxine (FT4) and TSH …

Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function

X Ke, X Tian, S Yao, H Wu, YY Duan… - Human Molecular …, 2022 - academic.oup.com
Thyroid dysfunction is a common endocrine disease measured by thyroid-stimulating
hormone (TSH) level. Although> 70 genetic loci associated with TSH have been reported …

Mendelian Randomisation Analysis Suggests that Hypothyroidism Reduces Endometrial Cancer Risk

DM Glubb, X Wang, TA O'Mara - medRxiv, 2023 - medrxiv.org
Background Thyroid dysfunction, hypothyroidism in particular, has been associated with
endometrial cancer, but it remains unclear whether hypothyroidism itself or other aspects of …