Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Design and development of benzyl piperazine linked 5-phenyl-1, 2, 4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease
Our present work demonstrates the molecular hybridization-assisted design, synthesis, and
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat …
A series of some novel compounds (SD-1–17) were designed following a molecular
hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1 …
hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1 …
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
At present, one of the most promising strategies to tackle the complex challenges posed by
Alzheimer's disease (AD) involves the development of novel multitarget-directed ligands …
Alzheimer's disease (AD) involves the development of novel multitarget-directed ligands …
Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer's Disease Therapy
An efficient and promising method of treating complex neurodegenerative diseases like
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Outcome of resveratrol and resveratrol with donepezil combination on the β-amyloid plaques and neurofibrillary tangles in Alzheimer's disease
The goal of this research was to study the effect of different doses of resveratrol (RS) and RS
with donepezil (DPZ) on the deposition of amyloid beta (Aβ) and neurofibrillary tangles …
with donepezil (DPZ) on the deposition of amyloid beta (Aβ) and neurofibrillary tangles …
Design, synthesis, and biological evaluation of some 2-(3-oxo-5, 6-diphenyl-1, 2, 4-triazin-2 (3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease …
Inspite of established symptomatic relief drug targets, a multi targeting approach is highly in
demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE) …
demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE) …
Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting …
Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …
contemporary society, and many efforts have been made to overcome and (or) control it. In …
Indole 3 carbinol attenuated memory impairment, oxidative stress, inflammation, and apoptosis in bilateral common carotid artery occlusion induced brain damage in …
Y Srikanth, T Julius, M Gayathri, HS Tuyishime… - 3 Biotech, 2025 - Springer
Global cerebral ischemia (GCI) is associated with a multifaceted etiology, including
increased oxidative stress, inflammation, and elevated acetylcholinesterase (AChE) activity …
increased oxidative stress, inflammation, and elevated acetylcholinesterase (AChE) activity …