Targeting neuronal epigenomes for brain rejuvenation
S Zocher - The EMBO journal, 2024 - embopress.org
Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …
and possible interventions to prevent this cognitive decline have been the focus of intense …
MeCP2: a critical regulator of chromatin in neurodevelopment and adult brain function
Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …
Neuronal ensemble-specific DNA methylation strengthens engram stability
Memories are encoded by memory traces or engrams, represented within subsets of
neurons that are synchronously activated during learning. However, the molecular …
neurons that are synchronously activated during learning. However, the molecular …
MECP2 and the biology of MECP2 duplication syndrome
SR D'Mello III - Journal of Neurochemistry, 2021 - Wiley Online Library
Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …
predominantly males, is caused by duplication of the chromosomal region containing the …
A putative role for lncRNAs in epigenetic regulation of memory
The central dogma of molecular genetics is defined as encoded genetic information within
DNA, transcribed into messenger RNA, which contain the instructions for protein synthesis …
DNA, transcribed into messenger RNA, which contain the instructions for protein synthesis …
Maternal experience-dependent cortical plasticity in mice is circuit-and stimulus-specific and requires MECP2
The neurodevelopmental disorder Rett syndrome is caused by mutations in the gene
Mecp2. Misexpression of the protein MECP2 is thought to contribute to neuropathology by …
Mecp2. Misexpression of the protein MECP2 is thought to contribute to neuropathology by …
MeCP2 ubiquitination and sumoylation, in search of a function
L Kalani, BH Kim, JB Vincent… - Human Molecular …, 2024 - academic.oup.com
Abstract MeCP2 (Methyl CpG binding protein 2) is an intrinsically disordered protein that
binds to methylated genome regions. The protein is a critical transcriptional regulator of the …
binds to methylated genome regions. The protein is a critical transcriptional regulator of the …
Stress‐Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders
X Wang, D Liu, F Wei, Y Li, X Wang, L Li… - Neural …, 2020 - Wiley Online Library
Ras‐related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase that is well known for
its sensitivity to the environmental stress of a cell or an organism. It senses the external …
its sensitivity to the environmental stress of a cell or an organism. It senses the external …
Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors
J Santos‐Terra, I Deckmann… - International Journal …, 2021 - Wiley Online Library
Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …
Selective deletion of Methyl CpG binding protein 2 from parvalbumin interneurons in the auditory cortex delays the onset of maternal retrieval in mice
DD Rupert, AH Pagliaro, J Choe… - Journal of …, 2023 - Soc Neuroscience
Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome. MECP2 codes
for methyl CpG binding protein 2 (MECP2), a transcriptional regulator that activates genetic …
for methyl CpG binding protein 2 (MECP2), a transcriptional regulator that activates genetic …