Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or
mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 …

The p53 tumor suppressor gene is commonly altered in human tumors, predominantly
through missense mutations that result in accumulation of mutant p53 protein. These …

Many p53 missense mutations possess dominant-negative activity and oncogenic gain of
function. We report that for structurally destabilized p53 mutants, these effects result from …

Mutations in the tumor suppressor gene TP53 are frequent in most human cancers.
Comparison of the mutation patterns in different cancers may reveal clues on the natural …

The p53 guardian of the genome is inactivated in the majority of cancers, mostly through
missense mutations that cause single residue changes in the DNA binding core domain of …

The transcription factor p53 plays a key role in the cellular defense against cancer
development. It is inactivated in virtually every tumor, and in every second tumor this …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

Mutations in the TP53 (p53) gene are present in a large fraction of human tumours, which
frequently express mutant p53 proteins at high but heterogeneous levels. The clinical …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …