Development of prefrontal cortex
During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Mitochondrial proteins encoded by the 22q11. 2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation
Microdeletion of a 3Mb region encompassing 45 protein-coding genes at chromosome
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …
Longitudinal trajectories of cortical development in 22q11. 2 copy number variants and typically develo** controls
Probing naturally-occurring, reciprocal genomic copy number variations (CNVs) may help us
understand mechanisms that underlie deviations from typical brain development. Cross …
understand mechanisms that underlie deviations from typical brain development. Cross …
Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence
Copy number variations (CNVs) are rare genomic deletions and duplications that can affect
brain and behaviour. Previous reports of CNV pleiotropy imply that they converge on shared …
brain and behaviour. Previous reports of CNV pleiotropy imply that they converge on shared …
Rethinking the first episode of schizophrenia: identifying convergent mechanisms during development and moving toward prediction
The neurodevelopmental hypothesis of schizophrenia has long suggested that the cardinal
psychotic symptoms that have traditionally defined the disorder, and which most commonly …
psychotic symptoms that have traditionally defined the disorder, and which most commonly …
Structural and functional brain alterations revealed by neuroimaging in CNV carriers
Copy Number Variants (CNVs) are associated with elevated rates of neuropsychiatric
disorders. A 'genetics-first'approach, involving the CNV effects on the brain, irrespective of …
disorders. A 'genetics-first'approach, involving the CNV effects on the brain, irrespective of …
Contribution of schizophrenia polygenic burden to longitudinal phenotypic variance in 22q11. 2 deletion syndrome
Abstract While the recurrent 22q11. 2 deletion is one of the strongest genetic risk factors for
schizophrenia (SCZ), variability of its associated neuropsychiatric endophenotypes reflects …
schizophrenia (SCZ), variability of its associated neuropsychiatric endophenotypes reflects …
Why does the face predict the brain? Neural crest induction, craniofacial morphogenesis, and neural circuit development
AS LaMantia - Frontiers in Physiology, 2020 - frontiersin.org
Mesenchephalic and rhombencephalic neural crest cells generate the craniofacial skeleton,
special sensory organs, and subsets of cranial sensory receptor neurons. They do so while …
special sensory organs, and subsets of cranial sensory receptor neurons. They do so while …
SNAREs and developmental disorders
BL Tang - Journal of cellular physiology, 2021 - Wiley Online Library
Members of the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor
(SNARE) family mediate membrane fusion processes associated with vesicular trafficking …
(SNARE) family mediate membrane fusion processes associated with vesicular trafficking …