Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Iron can affect the clinical course of several chronic metabolic diseases such as type 2
diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Iron overload can …

The β-thalassemia syndromes reflect deficient or absent β-globin synthesis usually owing to
a mutation in the β-globin locus. The relative excess of α-globin results in the formation of …

Iron overload and iron toxicity, whether because of increased absorption or iron loading from
repeated transfusions, can be major causes of morbidity and mortality in a number of chronic …

Both primary and secondary iron overload are increasingly prevalent in the United States
because of immigration from the Far East, increasing transfusion therapy in sickle cell …

Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common
genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage …

Iron overload is becoming an increasing problem as haemoglobinopathy patients gain
greater access to good medical care and as therapies for myelodysplastic syndromes …

Anemia is often associated with diabetes mellitus and is known to intensify the risk of
develo** diabetes-related microvascular and macrovascular complications. There is …

Excessive adiposity is associated with several metabolic perturbations including
disturbances in iron homeostasis. Increased systemic inflammation in obesity stimulates …

Treatment of iron overload requires robust estimates of total body iron burden and its
response to iron chelation therapy. Compliance with chelation therapy varies considerably …