Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39
conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP–P2 …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Abstract LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP,
hCAP18), reportedly increases resistance to microbial invasion and exerts important …

Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO)
constitute an intrinsic part of immunological network in tumor immunity. The concentrations …

Abstract Immunogenic Cell Death (ICD) is a type of cell death that kills tumor cells by
stimulating the adaptive immune response against other tumor cells. ICD depends on the …

Cancer is a major public health problem and the second leading cause of mortality around
the world. Although continuous advances in the science of oncology and cancer research …