The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Alterations in water homeostasis can disturb cell size and function. Although most cells can
internally regulate cell volume in response to osmolar stress, neurons are particularly at risk …

Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

Plasma membranes provide an effective barrier to the extracellular environment. Water was
long believed to move through lipid bilayers by simple diffusion; however, membranes from …

Renal interstitial fibrosis and tubular atrophy are essential pathological characteristics of
chronic renal allograft dysfunction (CAD). Herein, we revealed that ferroptosis of renal …

The mammalian kidney is multiform. The basic architecture is best understood in the
unipapillary kidney, which is common in all small species. A coronal section of this kidney …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

Aquaporin water channels are a family of membrane proteins that facilitate water movement
across biological membranes. Aquaporin-1 (AQP-1) has been found to be important in …