Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

Background Idiopathic membranous nephropathy, a common form of the nephrotic
syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis …

Rapid internalization of the cell surface low density lipoprotein (LDL) receptor requires the
first 22 amino acids of the cytoplasmic domain (residues 790-811), which must include an …

We report the use of the autofluorescent compound monodansylcadaverine (MDC) for in
vivo labeling of autophagic vacuoles. When applied to various cell types (PaTu 8902, MDCK …

Membranous nephropathy is a major cause of nephrotic syndrome of non-diabetic origin in
adults. It is the second or third leading cause of end-stage renal disease in patients with …

The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic
membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is …

Progression of glomerular diseases: Is the podocyte the culprit? The stereotyped
development of the glomerular lesions in many animal models and human forms of …

Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …

The hallmark of membranous glomerulonephritis, a major primary nephropathy, is the
presence of immune deposits on the outer aspect of the glomerular basement membrane …