Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
Therapeutic targeting of regulatory T cells in cancer
F Shan, A Somasundaram, TC Bruno, CJ Workman… - Trends in cancer, 2022 - cell.com
The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
Current immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of
humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in …
humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells
Regulatory T cells (Treg cells) can activate multiple suppressive mechanisms in vitro after
activation via the T cell antigen receptor, resulting in antigen-independent suppression …
activation via the T cell antigen receptor, resulting in antigen-independent suppression …
Crosstalk between regulatory T cells and tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer
JE Jang, CH Hajdu, C Liot, G Miller, ML Dustin… - Cell reports, 2017 - cell.com
Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal
adenocarcinoma (PDA). However, the immunomodulatory function of Treg cells in PDA is …
adenocarcinoma (PDA). However, the immunomodulatory function of Treg cells in PDA is …
Modulation of regulatory T cell function and stability by co-inhibitory receptors
Regulatory T (Treg) cells constitute a dynamic population that is essential for controlling
immune responses in health and disease. Defects in Treg cell function and decreases in …
immune responses in health and disease. Defects in Treg cell function and decreases in …
Molecular mechanisms of treg-mediated T cell suppression
A Schmidt, N Oberle, PH Krammer - Frontiers in immunology, 2012 - frontiersin.org
CD4+ CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and,
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
Foxp3+ CD4+ T helper cells called regulatory T (T reg) cells play a key role in controlling
reactivity to self-antigens and onset of autoimmunity. T reg cells either arise in thymus and …
reactivity to self-antigens and onset of autoimmunity. T reg cells either arise in thymus and …
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
JM Weiss, AM Bilate, M Gobert, Y Ding… - Journal of Experimental …, 2012 - rupress.org
Foxp3 activity is essential for the normal function of the immune system. Two types of
regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and …
regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and …