G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

The α‐chemokine stromal‐derived factor (SDF)‐1 and the G‐protein–coupled seven‐span
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

JunD regulates genes involved in antioxidant defence. We took advantage of the chronic
oxidative stress resulting from junD deletion to examine the role of reactive oxygen species …

Every year about 500,000 people in the United States die as a result of cancer. Among them,
90% exhibit systemic disease with metastasis. Considering this high rate of incidence and …

Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants
plays a pivotal role in organ development and renewal/regeneration of damaged tissues …

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The
metastatic pathway describes the process by which cancer cells give rise to a metastatic …

Although millions of cells are shed from a tumour every day, haematogenous metastasis is
believed to be very inefficient. This inefficiency is widely assumed to be a result of the …

Purpose: CXCR4 receptor and its unique ligand, the CXCL12 chemokine, have been
recently implicated in cancer metastasis. Evidence about the role of CXCR4/CXCL12 axis …

Mechanisms by which Wnt pathways integrate the organization of receptors, organelles, and
cytoskeletal proteins to confer cell polarity and directional cell movement are incompletely …