Although it is now relatively well understood how sequence defines and impacts global
protein stability in specific structural contexts, the question of how sequence modulates the …

The chemical and structural properties of biomolecules determine their interactions, and
thus their functions, in a wide variety of biochemical processes. Innovative imaging methods …

Buoyancy acting on plankton, ie the difference in specific gravity between plankton and the
ambient water, is a function of salinity and temperature. From specific gravity measurements …

Scalable tracers are potentially a useful tool to examine diffusion mechanisms and to predict
diffusion coefficients, particularly for hindered diffusion in complex, heterogeneous, or …

Our understanding of how enzymes work is coloured by static structure depictions where the
enzyme scaffold is presented as either immobile, or in equilibrium between well‐defined …

Pressure and temperature are the two fundamental variables of thermodynamics.
Temperature and chemical perturbation are central experimental tools for the exploration of …

The overall charge content and the patterning of charged residues have a profound impact
on the conformational ensembles adopted by intrinsically disordered proteins. These …

A complete description of the pathways and mechanisms of protein folding requires a
detailed structural and energetic characterization of the conformational ensemble along the …

Pressure is a well-known environmental stressor that can either stabilize or destabilize
proteins. The volumetric change upon protein unfolding determines the effect of pressure on …

The way in which the network of intramolecular interactions determines the cooperative
folding and conformational dynamics of a protein remains poorly understood. High-pressure …