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Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties …
A Šmelcerović, K Tomović, Ž Šmelcerović… - European journal of …, 2017 - Elsevier
Xanthine oxidase (XO), a versatile metalloflavoprotein enzyme, catalyzes the oxidative
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
The interaction between dietary fructose and gut microbiota in hyperuricemia and gout
X Fang, L Qi, H Chen, P Gao, Q Zhang, R Leng… - Frontiers in …, 2022 - frontiersin.org
With the worldwide epidemics of hyperuricemia and associated gout, the diseases with
purine metabolic disorders have become a serious threat to human public health …
purine metabolic disorders have become a serious threat to human public health …
Intestinal microbiota distinguish gout patients from healthy humans
Current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic.
Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that …
Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that …
Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes
Novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase
isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase …
isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase …
[HTML][HTML] Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail
Background High-purine diet can cause gut microbiota disorder, which is closely related to
the occurrence of hyperuricemia (HUA). At the same time, the development of HUA is often …
the occurrence of hyperuricemia (HUA). At the same time, the development of HUA is often …
Toward an understanding of structural insights of xanthine and aldehyde oxidases: an overview of their inhibitors and role in various diseases
Almost all drug molecules become the substrates for oxidoreductase enzymes, get
metabolized into more hydrophilic products and eliminated from the body. These …
metabolized into more hydrophilic products and eliminated from the body. These …
Inhibitors of xanthine oxidase: scaffold diversity and structure‐based drug design
Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines and their
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …
The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation
J Han, Z Wang, C Lu, J Zhou, Y Li, T Ming, Z Zhang… - Food & Function, 2021 - pubs.rsc.org
Hyperuricaemia is a disease associated with elevated serum uric acid content, which has
emerged rapidly in recent decades. The drugs used to treat clinical hyperuricaemia have …
emerged rapidly in recent decades. The drugs used to treat clinical hyperuricaemia have …
Folic acid and zinc improve hyperuricemia by altering the gut microbiota of rats with high-purine diet-induced hyperuricemia
X Sun, J Wen, B Guan, J Li, J Luo, J Li, M Wei… - Frontiers in …, 2022 - frontiersin.org
A high-purine diet can cause hyperuricemia and destroy the microbial composition of the gut
microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate …
microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate …
An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015)
Introduction: Xanthine oxidase (XO) is a versatile molybdoflavoprotein, widely distributed,
occurring in milk, kidney, lung, heart, and vascular endothelium. Catalysis by XO to produce …
occurring in milk, kidney, lung, heart, and vascular endothelium. Catalysis by XO to produce …