Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals
that modulate T cell differentiation. While the role of DCs in adaptive immunity is well …

Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …

The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial
effects in a range of human disorders associated with inflammation including cardiovascular …

Dendritic cells (DCs), a type of professional antigen-presenting cells, are responsible for
initiation and maintenance of immune responses. Here we report that a substantial …

Inflammation is a protective response essential for maintaining human health and for fighting
disease. As an active innate immune reaction to challenge, inflammation gives rise to …

Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …

The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …