Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

The structural and functional integrity of the brain depends on the delicate balance between
substrate delivery through blood flow and energy demands imposed by neural activity …

INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …

Implementation of amyloid biomarkers in clinical practice would be accelerated if such
biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …

Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative
condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in …

The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …

The market for neuropharmaceuticals is potentially one of the largest sectors of the global
pharmaceutical market owing to the increase in average life expectancy and the fact that …

Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Pericytes are cells in the blood–brain barrier (BBB) that degenerate in A lzheimer's disease
(AD), a neurodegenerative disorder characterized by early neurovascular dysfunction …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …