Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

For several decades there has been accumulating evidence implicating type I interferons
(IFNs) as key elements of the immune response. Therapeutic approaches incorporating …

Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …

The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …

The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs,
radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer
patients still do not respond. We now find that immunotherapy can induce stem-like …

Telomeres, the protective structures of chromosome ends are gradually shortened by each
cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Abstract Purpose: Cyclin-dependent kinase 4 (CDK4) and CDK6 inhibitors (CDK4/6i) are
highly effective against estrogen receptor–positive (ER+)/HER2− breast cancer; however …