Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

Cellular communication can be mediated by the exchange of biological information, mainly
in the form of proteins and RNAs. This can occur when extracellular vesicles, such as …

Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

Multivesicular bodies are key endosomal compartments implicated in cellular quality control
through their degradation of membrane-bound cargo proteins,–. The ATP-consuming …

The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

When internalized receptors and other cargo are destined for lysosomal degradation, they
are ubiquitinated and sorted by the endosomal sorting complex required for transport …