The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Purpose Muscle atrophy is a frequent complication of chronic kidney disease (CKD) and is
associated with increased morbidity and mortality. The processes causing loss of muscle …

The aim of the present study was to investigate the effects of NMDA receptor blockade on
formation of object recognition memory. In the first experiment, adult Wistar rats were given …

We have characterised the effects of the recently described NMDA NR2B subtype selective
antagonist, Ro 63-1908, on spontaneous behaviour and in tasks sensitive to non-selective …

NR2B antagonists have received considerable attention in recent years. In this class of
excitatory amino acid receptor antagonists NR2B antagonists have shown efficacy in …

Rationale We previously reported that the NR2B subunit-selective N-methyl-d-aspartate
(NMDA) antagonist Ro 63-1908 produced a marked deficit in response control in the five …

Rationale The ionotropic NMDA glutamate receptor is composed of NR1 and NR2 (NR2A-D)
subunits. While there is compelling evidence that NMDA receptors modulate behavioral …

Over activation of the NMDA receptor complex has been implicated in a number of
neurological conditions. The use of NMDA antagonists as therapeutic agents has been …

The role of 5-HT7 receptor has been demonstrated in various animal models of mood
disorders; however its function in cognition remains largely speculative. This study evaluates …

Working memory is a type of short-term memory involved in the maintenance and
manipulation of information essential for complex cognition. While memory span capacity …