The modification of proteins and other biomolecules with the small protein ubiquitin has
enthralled scientists from many disciplines for decades, creating a broad research field …

There is growing interest in designing multidrug therapies that leverage tradeoffs to combat
resistance. Tradeoffs are common in evolution and occur when, for example, resistance to …

Abstract The E2 ubiquitin (Ub)-conjugating enzyme primarily determines Ub conjugation as
Ub-isopeptide (lysine), Ub-oxyester (serine/threonine) or Ub-thioester (cysteine). However …

There is growing interest in designing multidrug therapies that leverage tradeoffs to combat
resistance. Tradeoffs are common in evolution and occur when, for example, resistance to …

Most of the fundamental processes of cells are mediated by proteins. However, the
biologically-relevant mechanism of most proteins are poorly understood. Dominant negative …

Dominant negative (DN) mutations provide valuable tools for investigating protein
mechanisms but can be difficult to isolate because of their toxic effects. We used a …

There is growing interest in designing multidrug therapies that leverage tradeoffs to combat
drug resistance. Tradeoffs are common in evolution and occur when, for example, resistance …

During infection some pathogenic gram-negative bacteria, such as Salmonella, manipulate
the host ubiquitination system through the delivery of secreted effectors known as novel E3 …

Protein oligomerization is a fundamental, yet a complex process adapted by the cell to
evolve proteins with diverse or efficient functions and enhanced stability. This evolutionary …

During infection some pathogenic gram-negative bacteria, such as Salmonella, manipulate
the host ubiquitination system through the delivery of secreted effectors known as novel E3 …