Blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy

X Peng, Z Luo, S He, L Zhang, Y Li - Frontiers in cellular and infection …, 2021 - frontiersin.org
As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders

JJ Lochhead, J Yang, PT Ronaldson… - Frontiers in physiology, 2020 - frontiersin.org
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Dual-responsive biohybrid neutrobots for active target delivery

H Zhang, Z Li, C Gao, X Fan, Y Pang, T Li, Z Wu… - Science Robotics, 2021 - science.org
Swimming biohybrid microsized robots (eg, bacteria-or sperm-driven microrobots) with self-
propelling and navigating capabilities have become an exciting field of research, thanks to …

In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use

HC Helms, NJ Abbott, M Burek… - Journal of Cerebral …, 2016 - journals.sagepub.com
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Biomimetic Nanocomposites Camouflaged with Hybrid Cell Membranes for Accurate Therapy of Early‐Stage Glioma

S Chi, L Zhang, H Cheng, Y Chang, Y Zhao… - Angewandte …, 2023 - Wiley Online Library
Glioma features high fatality rate and short survival time of patients due to its fast growth
speed and high invasiveness, hence timely treatment of early‐stage glioma is extremely …

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

M Agrawal, DK Tripathi, S Saraf, S Saraf… - Journal of controlled …, 2017 - Elsevier
In this modern era, with the help of various advanced technologies, medical science has
overcome most of the health-related issues successfully. Though, some diseases still remain …

[HTML][HTML] Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in …

Y Han, C Gao, H Wang, J Sun, M Liang, Y Feng, Q Liu… - Bioactive materials, 2021 - Elsevier
Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is
an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic …

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

R Booth, H Kim - Lab on a Chip, 2012 - pubs.rsc.org
The blood-brain barrier (BBB), a unique selective barrier for the central nervous system
(CNS), hinders the passage of most compounds to the CNS, complicating drug …

Blood-brain barrier transport machineries and targeted therapy of brain diseases

J Barar, MA Rafi, MM Pourseif, Y Omidi - BioImpacts: BI, 2016 - pmc.ncbi.nlm.nih.gov
Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely
depends upon the safe drug delivery into the brain parenchyma. However, due to the robust …

Delivering antisense oligonucleotides across the blood‐brain barrier by tumor cell‐derived small apoptotic bodies

Y Wang, J Pang, Q Wang, L Yan, L Wang… - Advanced …, 2021 - Wiley Online Library
The blood‐brain barrier (BBB) is the most restrictive and complicated barrier that keeps most
biomolecules and drugs from the brain. An efficient brain delivery strategy is urgently …