Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Mutations of the BRAF gene in human cancer
Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
JM Kyriakis, J Avruch - Physiological reviews, 2001 - journals.physiology.org
The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …
only begun to be dissected. This, despite the fact that the impact of these pathways on the …
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan, MJ Garnett, SM Roe, S Lee… - Cell, 2004 - cell.com
Over 30 mutations of the B-RAF gene associated with human cancers have been identified,
the majority of which are located within the kinase domain. Here we show that of 22 B-RAF …
the majority of which are located within the kinase domain. Here we show that of 22 B-RAF …
[HTML][HTML] Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
JA McCubrey, LS Steelman, WH Chappell… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit
signals from their receptors to regulate gene expression and prevent apoptosis. Some …
signals from their receptors to regulate gene expression and prevent apoptosis. Some …
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
W Kolch - Biochemical Journal, 2000 - portlandpress.com
The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
Regulation of RAF protein kinases in ERK signalling
H Lavoie, M Therrien - Nature reviews Molecular cell biology, 2015 - nature.com
RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
[HTML][HTML] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence
of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent …
of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent …