Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

Cultivating meat from muscle stem cells in vitro requires 3D edible scaffolds as the
supporting matrix. Electrohydrodynamic (EHD) printing is an emerging 3D‐printing …

The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …