Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage
breast cancer is considered a curable disease; however, once distant metastasis occurs, the …

Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies.
Although they were designed to target aberrant tyrosine kinases, they are also intimately …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

New, more effective therapeutics are required for the treatment of paediatric cancers.
Current treatment protocols of cytotoxic treatments including chemotherapy trigger cancer …

Compared with other breast cancer subtypes, triple-negative breast cancer (TNBC) is
associated with relatively poor outcomes due to its metastatic propensity, frequent failure to …

Patients with neuroblastoma due to MYCN oncogene amplification and consequent N‐Myc
oncoprotein overexpression have very poor prognosis. The cyclin‐dependent kinase 7 …

BRAF mutations occur in~ 10% of colorectal cancer (CRC) and are associated with poor
prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF …

Survivin, a member of the inhibitor of apoptosis family, is upregulated in multiple cancers
including ovarian cancer, but is rarely detectable in normal tissues. We previously reported …

An efficient gene-editing technique for use in human pluripotent stem cells (hPSCs) has
great potential value in regenerative medicine, as well as in drug discovery based on …