Linac coherent light source: The first five years
A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …
Serial femtosecond crystallography: the first five years
I Schlichting - IUCrJ, 2015 - journals.iucr.org
Protein crystallography using synchrotron radiation sources has had a tremendous impact
on biology, having yielded the structures of thousands of proteins and given detailed insight …
on biology, having yielded the structures of thousands of proteins and given detailed insight …
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Light-induced structural changes and the site of O= O bond formation in PSII caught by XFEL
Photosystem II (PSII) is a huge membrane-protein complex consisting of 20 different
subunits with a total molecular mass of 350 kDa for a monomer. It catalyses light-driven …
subunits with a total molecular mass of 350 kDa for a monomer. It catalyses light-driven …
[HTML][HTML] Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors
G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction
with arrestins, whose binding promotes receptor internalization and signaling through G …
with arrestins, whose binding promotes receptor internalization and signaling through G …
An oxyl/oxo mechanism for oxygen-oxygen coupling in PSII revealed by an x-ray free-electron laser
Photosynthetic water oxidation is catalyzed by the Mn4CaO5 cluster of photosystem II (PSII)
with linear progression through five S-state intermediates (S0 to S4). To reveal the …
with linear progression through five S-state intermediates (S0 to S4). To reveal the …
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
INTRODUCTION Retinal is a light-sensitive protein ligand that is used by all domains of life
to process the information and energy content of light. Retinal-binding proteins are integral …
to process the information and energy content of light. Retinal-binding proteins are integral …
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein
A variety of organisms have evolved mechanisms to detect and respond to light, in which the
response is mediated by protein structural changes after photon absorption. The initial step …
response is mediated by protein structural changes after photon absorption. The initial step …
A three-dimensional movie of structural changes in bacteriorhodopsin
Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport
protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron …
protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron …
Optical control of ultrafast structural dynamics in a fluorescent protein
The photoisomerization reaction of a fluorescent protein chromophore occurs on the ultrafast
timescale. The structural dynamics that result from femtosecond optical excitation have …
timescale. The structural dynamics that result from femtosecond optical excitation have …