Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They
are members of the Cys-loop family of ligand-gated ion channels which also include …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit …

We demonstrated previously that phosphocholine and phosphocholine-modified
macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and …

In contrast to mammals, birds recover naturally from acquired hearing loss, which makes
them an ideal model for inner ear regeneration research. Here, we present a validated …

Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

The transduction of sound in the auditory periphery, the cochlea, is inhibited by efferent
cholinergic neurons projecting from the brainstem and synapsing directly on …

The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …