▪ Abstract Many biological functions of heme oxygenase (HO), such as cytoprotection
against oxidative stress, vasodilation, neurotransmission in the central or peripheral nervous …

Transplantation of islet of Langerhans represents a viable therapeutic option for insulin-
dependent diabetes mellitus. Dramatic progress has been recently reported with the …

Increased production of reactive oxygen species contributes to the etiology of diabetes
complications. Pathophysiological stimuli that increase oxidative stress upregulate heme …

Summary Haem-oxygenase-1 (HO-1) has been shown to exert anti-inflammatory, anti-
apoptotic and anti-proliferative effects. We investigated HO-1 expression in patients with …

The increased prevalence of diabetes and associated complications presents a major health
risk worldwide, and requires an efficient management protocol. Type-1 and type-2 diabetes …

UV radiation-induced epidermal apoptotic sunburn cells provide a mechanism for
eliminating cells with irreparable DNA damage. The UVB (290–320 nm) waveband is mainly …

Clinical islet transplantation is a β‐cell replacement strategy that represents a possible
definitive intervention for patients with type 1 diabetes, offering substantial benefits in terms …

Background Islet transplantation represents an ideal therapeutic approach for treatment of
type 1 diabetes but islet function and regeneration may be influenced by necrosis or …

Summary Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal
tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 …

TNF-induced apoptosis is tightly regulated by the NF-κB pathway. Under physiologic
conditions, TNFα stimulation induces NF-κB activation and cell survival, due to the …