Pluripotent stem cells have the remarkable self-renewal ability and are capable of
differentiating into multiple diverse cells. There is increasing evidence that the aging process …

Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

The significant biochemical and physiological effects of psychological stress are beginning
to be recognized as exacerbating common diseases, including osteoporosis. This review …

In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …

Disrupted Wnt signaling in osteoblastic-lineage cells leads to bone formation defect in
osteoporosis. However, the factors repressing Wnt signaling are unclear. In our study, we …

During osteoporosis, the shift of mesenchymal stem cell (MSC) lineage commitment to
adipocyte leads to the imbalance between bone mass and fat, which increases the risk of …

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to self-renew
and multi-directional differentiation potential. Exogenously administered MSCs can migrate …

Diabetic osteoporosis (DOP) is a metabolic disease which is characterized by impaired
bone microarchitecture and reduced bone mineral density resulting from hyperglycemia …