Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders
F Nicoletti, L Di Menna, L Iacovelli, R Orlando… - …, 2023 - Elsevier
Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …
A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model
This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer's disease-
like condition to enhance translational research. Our review seeks to understand how MSG …
like condition to enhance translational research. Our review seeks to understand how MSG …
[HTML][HTML] Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors
F Bono, C Fiorentini, V Mutti, Z Tomasoni… - Pharmacological …, 2023 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the
peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on …
peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on …
Metabotropic glutamate receptor trafficking
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that
bind to the excitatory neurotransmitter glutamate and are important in the modulation of …
bind to the excitatory neurotransmitter glutamate and are important in the modulation of …
β-adrenergic receptors/epac signaling increases the size of the readily releasable pool of synaptic vesicles required for parallel fiber LTP
The second messenger cAMP is an important determinant of synaptic plasticity that is
associated with enhanced neurotransmitter release. Long-term potentiation (LTP) at parallel …
associated with enhanced neurotransmitter release. Long-term potentiation (LTP) at parallel …
Presynaptic release-regulating metabotropic glutamate receptors: an update
Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors
in mammals and act as fine tuners of the chemical transmission in central nervous system …
in mammals and act as fine tuners of the chemical transmission in central nervous system …
Enriched environment ameliorates chronic temporal lobe epilepsy‐induced behavioral hyperexcitability and restores synaptic plasticity in CA3–CA1 synapses in male …
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies.
Pharmacoresistance and comorbidities pose significant challenges to its treatment …
Pharmacoresistance and comorbidities pose significant challenges to its treatment …
The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
Abstract Background Fragile X syndrome (FXS), the most common inherited intellectual
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …
Study on analgesic effect of Shentong Zhuyu Decoction in neuropathic pain rats by network pharmacology and RNA-Seq
C Wang, J Lin, H **e, L Chen, P Chen, L Wu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Shentong Zhuyu Decoction (STZYD) is a
traditional prescription for promoting the flow of Qi and Blood which is often used in the …
traditional prescription for promoting the flow of Qi and Blood which is often used in the …