Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development

WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders

F Nicoletti, L Di Menna, L Iacovelli, R Orlando… - …, 2023 - Elsevier
Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model

SS Ankul, L Chandran, S Anuragh… - Frontiers in …, 2023 - frontiersin.org
This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer's disease-
like condition to enhance translational research. Our review seeks to understand how MSG …

[HTML][HTML] Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

F Bono, C Fiorentini, V Mutti, Z Tomasoni… - Pharmacological …, 2023 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the
peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on …

Metabotropic glutamate receptor trafficking

YH Suh, K Chang, KW Roche - Molecular and cellular neuroscience, 2018 - Elsevier
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that
bind to the excitatory neurotransmitter glutamate and are important in the modulation of …

β-adrenergic receptors/epac signaling increases the size of the readily releasable pool of synaptic vesicles required for parallel fiber LTP

R Martín, N García-Font, AS Suárez-Pinilla… - Journal of …, 2020 - Soc Neuroscience
The second messenger cAMP is an important determinant of synaptic plasticity that is
associated with enhanced neurotransmitter release. Long-term potentiation (LTP) at parallel …

Presynaptic release-regulating metabotropic glutamate receptors: an update

G Olivero, M Vergassola, F Cisani… - Current …, 2020 - ingentaconnect.com
Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors
in mammals and act as fine tuners of the chemical transmission in central nervous system …

Enriched environment ameliorates chronic temporal lobe epilepsy‐induced behavioral hyperexcitability and restores synaptic plasticity in CA3–CA1 synapses in male …

RJ Salaka, KP Nair, K Annamalai… - Journal of …, 2021 - Wiley Online Library
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies.
Pharmacoresistance and comorbidities pose significant challenges to its treatment …

The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

R Martín, AS Suárez-Pinilla, N García-Font… - Molecular autism, 2023 - Springer
Abstract Background Fragile X syndrome (FXS), the most common inherited intellectual
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …

Study on analgesic effect of Shentong Zhuyu Decoction in neuropathic pain rats by network pharmacology and RNA-Seq

C Wang, J Lin, H **e, L Chen, P Chen, L Wu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Shentong Zhuyu Decoction (STZYD) is a
traditional prescription for promoting the flow of Qi and Blood which is often used in the …