Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …

Reversibly altering endogenous protein levels are persistent issues. Herein, we designed
photoswitchable azobenzene-proteolysis targeting chimeras (Azo-PROTACs) by including …

Great success has been witnessed in last decades, some new techniques and strategies
have been widely used in drug discovery. In this roadmap, several representative …

The covalent conjugation of potent cytotoxic agents to either macromolecular carriers or
small molecules represents a well‐known approach to increase the therapeutic index of …

Photocleavable protecting groups (PPGs) enable the precise spatiotemporal control over the
release of a payload of interest, in particular a bioactive substance, through light irradiation …

Fluorescence probes with aggregation‐induced emission (AIE) property are fascinating and
vital in biological fields due to their bright fluorescence in the solid state. In contrast …

Control of biological function by the use of photoremovable protecting groups (PPGs) is a
gateway towards many new medical developments. Herein, we report the synthesis and …

Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …