The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Electrophysiology provides a real-time readout of neural functions and network capability in
different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and …

Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

Background Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently
observed in preclinical animal models of Alzheimer's disease (AD). This study investigates …

Cognitive dysfunction in Alzheimer's disease (AD) is caused by disturbances in neuronal
circuits of the brain underpinned by synapse loss, neuronal dysfunction and neuronal death …

Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …

Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …

Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the
leading cause of dementia worldwide, and is characterized by the accumulation of amyloid …

Epilepsy is a comorbidity associated with Alzheimer's disease (AD), often starting many
years earlier than memory decline. Investigating this association in the early pre …