NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Current genetic landscape in common variable immune deficiency
H Abolhassani, L Hammarström… - Blood, The Journal …, 2020 - ashpublications.org
Using whole-exome sequencing to examine the genetic causes of immune deficiency in 235
common variable immunodeficiency (CVID) patients seen in the United States (Mount Sinai …
common variable immunodeficiency (CVID) patients seen in the United States (Mount Sinai …
Whole-genome sequencing of patients with rare diseases in a national health system
Most patients with rare diseases do not receive a molecular diagnosis and the aetiological
variants and causative genes for more than half such disorders remain to be discovered …
variants and causative genes for more than half such disorders remain to be discovered …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
Humoral and cellular response following vaccination with the BNT162b2 mRNA COVID-19 vaccine in patients affected by primary immunodeficiencies
D Amodio, A Ruggiero, M Sgrulletti, C Pighi… - Frontiers in …, 2021 - frontiersin.org
Mass SARS-Cov-2 vaccination campaign represents the only strategy to defeat the global
pandemic we are facing. Immunocompromised patients represent a vulnerable population at …
pandemic we are facing. Immunocompromised patients represent a vulnerable population at …
Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis
H Ho, C Cunningham-Rundles - Frontiers in immunology, 2020 - frontiersin.org
Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic …
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic …
Common variable immunodeficiency: more pathways than roads to Rome
XP Peng, A Caballero-Oteyza… - Annual Review of …, 2023 - annualreviews.org
Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …
introduced to accommodate the many and varied antibody deficiencies being identified in …
Secondary immune deficiency and primary immune deficiency crossovers: hematological malignancies and autoimmune diseases
M Ballow, S Sánchez-Ramón, JE Walter - Frontiers in Immunology, 2022 - frontiersin.org
Primary immunodeficiencies (PIDs), a heterogenous group of inborn errors of immunity, are
predetermined at birth but may evolve with age, leading to a variable clinical and laboratory …
predetermined at birth but may evolve with age, leading to a variable clinical and laboratory …
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency
Autosomal dominant (AD) NFKB1 deficiency is thought to be the most common genetic
etiology of common variable immunodeficiency (CVID). However, the causal link between …
etiology of common variable immunodeficiency (CVID). However, the causal link between …