Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Endophytic fungi: Key insights, emerging prospects, and challenges in natural product drug discovery

P Tiwari, H Bae - Microorganisms, 2022 - mdpi.com
Plant-associated endophytes define an important symbiotic association in nature and are
established bio-reservoirs of plant-derived natural products. Endophytes colonize the …

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

PK Ajikumar, WH **ao, KEJ Tyo, Y Wang, F Simeon… - Science, 2010 - science.org
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific
yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here …

Multienzymatic cascade reactions via enzyme complex by immobilization

ET Hwang, S Lee - ACS Catalysis, 2019 - ACS Publications
Multienzymatic cascade reactions are a most important technology to succeed in industrial
process development, such as synthesis of pharmaceutical, cosmetic, and nutritional …

The medical application of terahertz technology in non-invasive detection of cells and tissues: opportunities and challenges

L Yu, L Hao, T Meiqiong, H Jiaoqi, L Wei, D **ying… - RSC …, 2019 - pubs.rsc.org
Terahertz (THz= 1012 Hz) spectroscopy has shown great potential in biomedical research
due to its unique features, such as the non-invasive and label-free identification of living …

Progress in Metabolic Engineering of Saccharomyces cerevisiae

E Nevoigt - Microbiology and Molecular Biology Reviews, 2008 - Am Soc Microbiol
The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has,
over time, resulted in substantial accumulated knowledge concerning genetics, physiology …

Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries

KK Hong, J Nielsen - Cellular and Molecular Life Sciences, 2012 - Springer
Metabolic engineering is the enabling science of development of efficient cell factories for
the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial …

Synthetic biology and the development of tools for metabolic engineering

JD Keasling - Metabolic engineering, 2012 - Elsevier
Synthetic biology can significantly advance metabolic engineering by contributing tools
(minimal hosts, vectors, genetic controllers, characterized enzymes). The development of …

Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

PK Ajikumar, K Tyo, S Carlsen, O Mucha… - Molecular …, 2008 - ACS Publications
Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

The future of metabolic engineering and synthetic biology: towards a systematic practice

VG Yadav, M De Mey, CG Lim, PK Ajikumar… - Metabolic …, 2012 - Elsevier
Industrial biotechnology promises to revolutionize conventional chemical manufacturing in
the years ahead, largely owing to the excellent progress in our ability to re-engineer cellular …