Since the first two complete bacterial genome sequences were published in 1995, the
science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is …

Reconstruction of target genomes from sequence data produced by instruments that are
agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …

Limitations of genome sequencing techniques have led to dozens of assembly algorithms,
none of which is perfect. A number of methods for comparing assemblers have been …

Background GC pairs are generally more stable than AT pairs; GC-rich genomes were
proposed to be more adapted to high temperatures than AT-rich genomes. Previous studies …

Based on complete bacterial genome sequence data, we demonstrate a correlation
between bacterial chromosome length and the G+ C content of the genome, with longer …

Since Jacob and Monod's characterization of the role of DNA elements in gene control, it
has been recognized that the linear organization of genome structure is important for the …

The genome sequencing of Buchnera aphidicola BCc from the aphid Cinara cedri, which is
the smallest known Buchnera genome, revealed that this bacterium had lost its symbiotic …

Metagenomics has become an integral part of defining microbial diversity in various
environments. Many ecosystems have characteristically low biomass and few cultured …

Background The core genome consists of genes shared by the vast majority of a species
and is therefore assumed to have been subjected to substantially stronger purifying …

Listeria monocytogenes strains are known to harbour plasmids that confer resistance to
sanitizers, heavy metals, and antibiotics; however, very little research has been conducted …