Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

Abstract Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required
for the development of T cells and for their persistence in the periphery. Unlike many other …

In T cell-deficient conditions, naïve T cells undergo spontaneous “homeostatic” proliferation
in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we …

Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …

▪ Abstract The factors affecting T cell viability vary depending on the type and status of the T
cell involved. Naïve T cells die via a Bcl-2/Bim dependent route. Their deaths are prevented …

Cytokines have proven to be effective for cancer therapy, however whilst low-dose
monotherapy with cytokines provides limited therapeutic benefit, high-dose treatment can …

Interleukin-7 (IL-7) is important for thymopoiesis in mice and humans because IL-7 receptor
α (IL-7Rα) mutations result in a severe combined immunodeficiency phenotype with severe …

Prolonged immunodeficiency after allogeneic bone marrow transplantation (BMT) causes
significant morbidity and mortality from infection. This study examined in murine models the …

The cell-intrinsic mechanisms guiding naive CD8+ T cells for clonal expansion and memory
generation via homeostatic proliferation (HP) are unclear. Here, we have shown that HP of …

The human fetus and neonate are unduly susceptible to infection with a number of bacterial,
fungal, protozoal, and viral agents, many of which are not pathogenic in older children and …