Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing

G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024 - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Molecular imaging and disease theranostics with renal-clearable optical agents

P Cheng, K Pu - Nature Reviews Materials, 2021 - nature.com
Optical imaging in disease diagnosis and treatment benefits from high spatiotemporal
resolution and the availability of numerous optical agents. However, many optical imaging …

Near-infrared fluorophores for biomedical imaging

G Hong, AL Antaris, H Dai - Nature biomedical engineering, 2017 - nature.com
In vivo near-infrared (NIR) fluorescence imaging is an emerging biomedical imaging
modality for use in both fundamental scientific research and clinical practice. Owing to …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications

X Zhao, F Zhang, Z Lei - Chemical Science, 2022 - pubs.rsc.org
Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II)
fluorophores, recently received increasing attention due to their high molar extinction …

Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging

DH Li, RS Gamage, AG Oliver, NL Patel… - Angewandte …, 2023 - Wiley Online Library
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

AL Antaris, H Chen, S Diao, Z Ma, Z Zhang… - Nature …, 2017 - nature.com
Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of
deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw …

Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color In Vivo Imaging with Shortwave Infrared Detection

ED Cosco, BA Arús, AL Spearman… - Journal of the …, 2021 - ACS Publications
Optical imaging within the shortwave infrared (SWIR, 1000–2000 nm) region of the
electromagnetic spectrum has enabled high-resolution and high-contrast imaging in mice …

Clearance pathways and tumor targeting of imaging nanoparticles

M Yu, J Zheng - ACS nano, 2015 - ACS Publications
A basic understanding of how imaging nanoparticles are removed from the normal
organs/tissues but retained in the tumors is important for their future clinical applications in …

Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …