HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively
expressed, cognate protein of the HSP70 family, which is central in many cellular processes …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

Functional proteins within cells are normally present in their native, completely folded form.
However, vital processes of protein biogenesis such as protein synthesis and translocation …

Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …

TWO cytosolic fractions (A and B) from Xenopus oocytes are sufficient to support protein
import into the nuclei of digitonin-permeabilized cells1. Fraction A recognizes the nuclear …

We have investigated a possible involvement of GTPases in nuclear protein import using an
in vitro transport system involving digitonin-permeabilized cells supplemented with …

The ubiquitous protein chaperone hsp90 has been shown to regulate more than 100
proteins involved in cellular signalling. These proteins are called 'client proteins' for hsp90 …

Through direct interaction with the voltage-dependent anion channel (VDAC), proapoptotic
members of the Bcl-2 family such as Bax and Bak induce apoptogenic cytochrome c release …

Nuclear protein transport is integral to eukaryotic cell processes such as differentiation,
transformation, and the control of gene expression. Although the targeting role of nuclear …

Chaperones/heat shock proteins (HSPs) of the HSP90 and HSP70 families show elevated
levels in proliferating mammalian cells and a cell cycle‐dependent expression. They …