Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …
The intricate organizational strategy of nucleus-forming phages
Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …
intricate structures for viral replication. Research on this newly appreciated family of phages …
[HTML][HTML] Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY
We recently discovered that some bacteriophages establish a nucleus-like replication
compartment (phage nucleus), but the core genes that define nucleus-based phage …
compartment (phage nucleus), but the core genes that define nucleus-based phage …
Nucleus-forming vibriophage cocktail reduces shrimp mortality in the presence of pathogenic bacteria
K Thammatinna, A Sinprasertporn, A Naknaen… - Scientific Reports, 2023 - nature.com
The global aquaculture industry has suffered significant losses due to the outbreak of Acute
Hepatopancreatic Necrosis Disease (AHPND) caused by Vibrio parahaemolyticus. Since …
Hepatopancreatic Necrosis Disease (AHPND) caused by Vibrio parahaemolyticus. Since …
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection
Large-genome bacteriophages (jumbo phages) of the proposed family Chimalliviridae
assemble a nucleus-like compartment bounded by a protein shell that protects the …
assemble a nucleus-like compartment bounded by a protein shell that protects the …
Microbial evolution through horizontal gene transfer by mobile genetic elements
M Tokuda, M Shintani - Microbial Biotechnology, 2024 - Wiley Online Library
Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …
[HTML][HTML] Sequential membrane-and protein-bound organelles compartmentalize genomes during phage infection
EG Armbruster, J Lee, J Hutchings, AR VanderWal… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Eukaryotic viruses assemble compartments required for genome replication, but no such
organelles are known to be essential for prokaryotic viruses. Bacteriophages of the family …
organelles are known to be essential for prokaryotic viruses. Bacteriophages of the family …
An essential and highly selective protein import pathway encoded by nucleus-forming phage
Targeting proteins to specific subcellular destinations is essential in prokaryotes,
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections
Antibiotic-resistant bacteria present an emerging challenge to human health. Their
prevalence has been increasing across the globe due in part to the liberal use of antibiotics …
prevalence has been increasing across the globe due in part to the liberal use of antibiotics …
Multi‐omics kinetic analysis of recombinant adeno‐associated virus production by plasmid transfection of HEK293 cells
Recombinant adeno‐associated virus (rAAV) is among the most commonly used vectors for
gene therapy. It is commonly produced by transfection of HEK293 cells with three plasmids …
gene therapy. It is commonly produced by transfection of HEK293 cells with three plasmids …