Oxidative damage in the central nervous system: protection by melatonin

RJ Reiter - Progress in neurobiology, 1998 - Elsevier
Melatonin was recently reported to be an effective free radical scavenger and antioxidant.
Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion …

Pharmacological actions of melatonin in oxygen radical pathophysiology

R Reiter, L Tang, JJ Garcia, A Muñoz-Hoyos - Life sciences, 1997 - Elsevier
Melatonin, the chief secretory product of the pineal gland, was recently found to be a free
radical scavenger and antioxidant. This review briefly summarizes the published reports …

Cell rearrangement and oxidant/antioxidant imbalance in Huntington's disease

F D'Egidio, V Castelli, A Cimini, M d'Angelo - Antioxidants, 2023 - mdpi.com
Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …

Neuroprotection in relation to retinal ischemia and relevance to glaucoma

NN Osborne, M Ugarte, M Chao, G Chidlow… - Survey of …, 1999 - Elsevier
Management of glaucoma is directed at the control of intraocular pressure (IOP), yet it is
recognized now that increased IOP is just an important risk factor in glaucoma. Therapy that …

Melatonin and cell death: differential actions on apoptosis in normal and cancer cells

RM Sainz, JC Mayo, C Rodriguez, DX Tan… - Cellular and Molecular …, 2003 - Springer
Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

M Majidinia, A Sadeghpour, S Mehrzadi… - Journal of pineal …, 2017 - Wiley Online Library
DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

[HTML][HTML] Antioxidants in Huntington's disease

A Johri, MF Beal - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2012 - Elsevier
Huntington's disease (HD) is a prototypical neurodegenerative disease in which there is
selective neuronal degeneration, which leads to progressive disability, manifesting itself as …

[HTML][HTML] The pilocarpine model of epilepsy: what have we learned?

FA Scorza, RM Arida… - Anais da Academia …, 2009 - SciELO Brasil
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Oxidative stress as a mechanism for quinolinic acid‐induced hippocampal damage: protection by melatonin and deprenyl

WMH Behan, M McDonald… - British journal of …, 1999 - Wiley Online Library
There are differences between the excitotoxic actions of quinolinic acid and N‐methyl‐d‐
aspartate (NMDA) which suggest that quinolinic acid may act by mechanisms additional to …

Reactive oxygen intermediates, molecular damage, and aging: relation to melatonin

RJ Reiter, JM Guerrero, JJ Garcia… - Annals of the New …, 1998 - Wiley Online Library
Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger
and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to …